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	<title>Comments on: The DIY Clinical Trial</title>
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	<description>Christopher Lydon in conversation on arts, ideas and politics</description>
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		<item>
		<title>By: joshjoshn</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-162669</link>
		<dc:creator>joshjoshn</dc:creator>
		<pubDate>Tue, 16 Dec 2008 21:10:52 +0000</pubDate>
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		<description>Here you can find observation data gathered by Canadian Clinic - Medicor Cancer
Centres durning DCA therapy:
medicorcancer.com/DCAtherapyData.html
and here are 4 cases treated with DCA:
forums.cancer.vc/respiratory-thoracic/158-case-study-1-mesothelioma-new-post.html
forums.cancer.vc/skin/157-case-study-2-melanoma-brain-metastases-new-post.html
medicorcancer.com/DCA-CaseStudy3.html
medicorcancer.com/DCA-CaseStudy4.html

here&#039;s an lymphoma remission story using DCA B1 vitamine protocol:
forums.cancer.vc/hematologic-blood/54-ds-lymphoma-story.html
and here are other remissions:

forums.cancer.vc/hematologic-blood/62-case-non-hodgkins-lymphoma-apparent-complete-remission.html
forums.cancer.vc/genitourinary-cancer/48-wim-huppes-prostate-cancer-story.html
forums.cancer.vc/genitourinary-cancer/55-ps-kidney-cancer-story.html
forums.cancer.vc/lung-cancer/56-tom-mcghees-nearly-full-remission-non-small-cell-lung-cancer.html
forums.cancer.vc/lung-cancer/63-lung-cancer-remission-dca.html
forums.cancer.vc/digestive-gastrointestinal/47-colo-rectal-cancer-story.html
forums.cancer.vc/digestive-gastrointestinal/57-bills-bile-duct-cancer-story.html
forums.cancer.vc/digestive-gastrointestinal/81-gastro-intestinal-stromal-tumors-dca.html 

for more info on alternative therapies and dca see forums.cancer.vc and for additional info see puredca.com and cancer.vc</description>
		<content:encoded><![CDATA[<p>Here you can find observation data gathered by Canadian Clinic &#8211; Medicor Cancer<br />
Centres durning DCA therapy:<br />
medicorcancer.com/DCAtherapyData.html<br />
and here are 4 cases treated with DCA:<br />
forums.cancer.vc/respiratory-thoracic/158-case-study-1-mesothelioma-new-post.html<br />
forums.cancer.vc/skin/157-case-study-2-melanoma-brain-metastases-new-post.html<br />
medicorcancer.com/DCA-CaseStudy3.html<br />
medicorcancer.com/DCA-CaseStudy4.html</p>
<p>here&#8217;s an lymphoma remission story using DCA B1 vitamine protocol:<br />
forums.cancer.vc/hematologic-blood/54-ds-lymphoma-story.html<br />
and here are other remissions:</p>
<p>forums.cancer.vc/hematologic-blood/62-case-non-hodgkins-lymphoma-apparent-complete-remission.html<br />
forums.cancer.vc/genitourinary-cancer/48-wim-huppes-prostate-cancer-story.html<br />
forums.cancer.vc/genitourinary-cancer/55-ps-kidney-cancer-story.html<br />
forums.cancer.vc/lung-cancer/56-tom-mcghees-nearly-full-remission-non-small-cell-lung-cancer.html<br />
forums.cancer.vc/lung-cancer/63-lung-cancer-remission-dca.html<br />
forums.cancer.vc/digestive-gastrointestinal/47-colo-rectal-cancer-story.html<br />
forums.cancer.vc/digestive-gastrointestinal/57-bills-bile-duct-cancer-story.html<br />
forums.cancer.vc/digestive-gastrointestinal/81-gastro-intestinal-stromal-tumors-dca.html </p>
<p>for more info on alternative therapies and dca see forums.cancer.vc and for additional info see puredca.com and cancer.vc</p>
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	<item>
		<title>By: TRKELEBEK</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-162598</link>
		<dc:creator>TRKELEBEK</dc:creator>
		<pubDate>Sat, 22 Nov 2008 13:01:59 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-162598</guid>
		<description>&lt;a href=&quot;http://www.trkelebek.net&quot; rel=&quot;nofollow&quot;&gt;kelebek&lt;/a&gt;
&lt;a href=&quot;http://www.trkelebek.net&quot; rel=&quot;nofollow&quot;&gt;kelebek script&lt;/a&gt;</description>
		<content:encoded><![CDATA[<p><a href="http://www.trkelebek.net" rel="nofollow">kelebek</a><br />
<a href="http://www.trkelebek.net" rel="nofollow">kelebek script</a></p>
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	<item>
		<title>By: kelebek</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-162536</link>
		<dc:creator>kelebek</dc:creator>
		<pubDate>Tue, 28 Oct 2008 19:31:45 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-162536</guid>
		<description>Medical Resource wrote an interesting post today onHere’s a quick excerpt</description>
		<content:encoded><![CDATA[<p>Medical Resource wrote an interesting post today onHere’s a quick excerpt</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: My Cancer Treatments  &#187; Blog Archive   &#187; in the &#34;The DIY Clinical Trial&#34; thread, My Cancer Treatments Â» Blog&#8230;</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-139720</link>
		<dc:creator>My Cancer Treatments  &#187; Blog Archive   &#187; in the &#34;The DIY Clinical Trial&#34; thread, My Cancer Treatments Â» Blog&#8230;</dc:creator>
		<pubDate>Sun, 22 Jun 2008 23:49:45 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-139720</guid>
		<description>[...]  &quot;The DIY Clinical Trial&quot; thread, My Cancer Treatments Â» Blog&#8230;  			 				  Medical Resource  wrote an interesting post today onHere&#8217;s a quick excerpt  [...]</description>
		<content:encoded><![CDATA[<p>[...]  &quot;The DIY Clinical Trial&quot; thread, My Cancer Treatments Â» Blog&#8230;  			 				  Medical Resource  wrote an interesting post today onHere&#8217;s a quick excerpt  [...]</p>
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	</item>
	<item>
		<title>By: My Cancer Treatments  &#187; Blog Archive   &#187; in the &#34;The DIY Clinical Trial&#34; thread, New Non-toxic Cancer&#8230;</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-139709</link>
		<dc:creator>My Cancer Treatments  &#187; Blog Archive   &#187; in the &#34;The DIY Clinical Trial&#34; thread, New Non-toxic Cancer&#8230;</dc:creator>
		<pubDate>Sun, 22 Jun 2008 22:59:19 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-139709</guid>
		<description>[...] 		in the &quot;The DIY Clinical Trial&quot; thread, New Non-toxic Cancer&#8230;  			 				  Medical Resource  wrote an interesting post today onHere&#8217;s a quick excerpt  [...]</description>
		<content:encoded><![CDATA[<p>[...] 		in the &quot;The DIY Clinical Trial&quot; thread, New Non-toxic Cancer&#8230;  			 				  Medical Resource  wrote an interesting post today onHere&#8217;s a quick excerpt  [...]</p>
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	</item>
	<item>
		<title>By: New Non-toxic Cancer Treatments. &#124; 7Wins.eu</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-139695</link>
		<dc:creator>New Non-toxic Cancer Treatments. &#124; 7Wins.eu</dc:creator>
		<pubDate>Sun, 22 Jun 2008 21:57:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-139695</guid>
		<description>[...] sarcoma of the liverNew Cancer Treatment Targets Both Tumor Cells And Blood Vessels &#124; iGlobOpen Source  » Blog Archive   » The DIY Clinical Trial    	Tags 	 [...]</description>
		<content:encoded><![CDATA[<p>[...] sarcoma of the liverNew Cancer Treatment Targets Both Tumor Cells And Blood Vessels | iGlobOpen Source  » Blog Archive   » The DIY Clinical Trial    	Tags 	 [...]</p>
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	<item>
		<title>By: jon_m</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-82130</link>
		<dc:creator>jon_m</dc:creator>
		<pubDate>Fri, 20 Jul 2007 22:39:39 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-82130</guid>
		<description>DCASite has been shut down by the FDA, at least for the moment - http://scienceblogs.com/insolence/2007/07/finally_the_fda_acts_on_thedcasitecom.php#more</description>
		<content:encoded><![CDATA[<p>DCASite has been shut down by the FDA, at least for the moment &#8211; <a href="http://scienceblogs.com/insolence/2007/07/finally_the_fda_acts_on_thedcasitecom.php#more" rel="nofollow">http://scienceblogs.com/insolence/2007/07/finally_the_fda_acts_on_thedcasitecom.php#more</a></p>
]]></content:encoded>
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	<item>
		<title>By: &#160; The DIY Clinical Trial&#160;by&#160;medTRIALS.info</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-81431</link>
		<dc:creator>&#160; The DIY Clinical Trial&#160;by&#160;medTRIALS.info</dc:creator>
		<pubDate>Thu, 12 Jul 2007 11:49:51 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-81431</guid>
		<description>[...]  Basically there&#8217;s a compound that has been shown to reduce &#8230; Original post by David delivered by Medtrials and StudyMe                        [...]</description>
		<content:encoded><![CDATA[<p>[...]  Basically there&#8217;s a compound that has been shown to reduce &#8230; Original post by David delivered by Medtrials and StudyMe </p>
<p>  [...]</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: medtrials.info  &#187; Blog Archive   &#187; The DIY Clinical Trial</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-81185</link>
		<dc:creator>medtrials.info  &#187; Blog Archive   &#187; The DIY Clinical Trial</dc:creator>
		<pubDate>Mon, 09 Jul 2007 01:21:12 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-81185</guid>
		<description>[...]  Basically there&#8217;s a compound that has been shown to reduce &#8230; Original post by David and Medtrials  				 				 					 						This entry was posted 												on W [...]</description>
		<content:encoded><![CDATA[<p>[...]  Basically there&#8217;s a compound that has been shown to reduce &#8230; Original post by David and Medtrials  				 				 					 						This entry was posted 												on W [...]</p>
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	</item>
	<item>
		<title>By: jon_m</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-81015</link>
		<dc:creator>jon_m</dc:creator>
		<pubDate>Thu, 05 Jul 2007 20:55:34 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-81015</guid>
		<description>definitely an interesting idea for a show, but it&#039;s worth remembering that the DCAsite and attempts at an &#039;open source trial&#039; have been very controversial.  See for example the debate on scienceblogs.com (summarised here - http://scienceblogs.com/insolence/2007/05/clinical_research_on_dichloroacetate_by_1.php).

To be blunt, it&#039;s quite possible that an &#039;open source trial&#039; of DCA could - in many ways be worse than Big Pharma&#039;s business as usual.  Getting people opposed to the &#039;open source trial&#039; of DCA to speak - as well as those supporting and/or profiting from this &#039;trial&#039; - could make for a very interesting debate.</description>
		<content:encoded><![CDATA[<p>definitely an interesting idea for a show, but it&#8217;s worth remembering that the DCAsite and attempts at an &#8216;open source trial&#8217; have been very controversial.  See for example the debate on scienceblogs.com (summarised here &#8211; <a href="http://scienceblogs.com/insolence/2007/05/clinical_research_on_dichloroacetate_by_1.php)" rel="nofollow">http://scienceblogs.com/insolence/2007/05/clinical_research_on_dichloroacetate_by_1.php)</a>.</p>
<p>To be blunt, it&#8217;s quite possible that an &#8216;open source trial&#8217; of DCA could &#8211; in many ways be worse than Big Pharma&#8217;s business as usual.  Getting people opposed to the &#8216;open source trial&#8217; of DCA to speak &#8211; as well as those supporting and/or profiting from this &#8216;trial&#8217; &#8211; could make for a very interesting debate.</p>
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	<item>
		<title>By: allison</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-78298</link>
		<dc:creator>allison</dc:creator>
		<pubDate>Tue, 26 Jun 2007 20:35:59 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-78298</guid>
		<description>It is interesting this question of how to navigate the medical system vis-a-vis doctors/pharmas/insurers. I&#039;m living this nightmare as we speak. I&#039;m clearly not an objective voice on this subject.

I can say that if someone wanted to do a clinical trial of a closer to natural product than most pharmas create, I would likely volunteer to participate.

I can also say that the way the system is devised, I am fearful of discussing what it takes for me to navigate my health care. Ironically, as someone who has adhered to a very healthy lifestyle - natural whole foods, no smoking, very little alchoholic consumption, a life of exercise, etc - I must fear the system. I try in every way I can to keep my treatment as low-cost and as whole-health supporting as possible. I end up paying out of pocket for most of my health care, though I&#039;m &quot;fully&quot; insured. You&#039;d think I would be the ideal patient and insurance customer. In our system, the ideal patient/customer is one who doesn&#039;t ask questions and just follows the doctors/insurers orders, regardless of whether they are wise. So, I can absolutely see why a group of patients would take things into their own hands. Particularly when they&#039;ve been abandoned to die.</description>
		<content:encoded><![CDATA[<p>It is interesting this question of how to navigate the medical system vis-a-vis doctors/pharmas/insurers. I&#8217;m living this nightmare as we speak. I&#8217;m clearly not an objective voice on this subject.</p>
<p>I can say that if someone wanted to do a clinical trial of a closer to natural product than most pharmas create, I would likely volunteer to participate.</p>
<p>I can also say that the way the system is devised, I am fearful of discussing what it takes for me to navigate my health care. Ironically, as someone who has adhered to a very healthy lifestyle &#8211; natural whole foods, no smoking, very little alchoholic consumption, a life of exercise, etc &#8211; I must fear the system. I try in every way I can to keep my treatment as low-cost and as whole-health supporting as possible. I end up paying out of pocket for most of my health care, though I&#8217;m &#8220;fully&#8221; insured. You&#8217;d think I would be the ideal patient and insurance customer. In our system, the ideal patient/customer is one who doesn&#8217;t ask questions and just follows the doctors/insurers orders, regardless of whether they are wise. So, I can absolutely see why a group of patients would take things into their own hands. Particularly when they&#8217;ve been abandoned to die.</p>
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	<item>
		<title>By: Treat-Cancer.nl</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-74690</link>
		<dc:creator>Treat-Cancer.nl</dc:creator>
		<pubDate>Sun, 24 Jun 2007 15:23:34 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-74690</guid>
		<description>http://www.treat-cancer.nl</description>
		<content:encoded><![CDATA[<p><a href="http://www.treat-cancer.nl" rel="nofollow">http://www.treat-cancer.nl</a></p>
]]></content:encoded>
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	<item>
		<title>By: W.M. Palmer</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-73423</link>
		<dc:creator>W.M. Palmer</dc:creator>
		<pubDate>Sat, 23 Jun 2007 17:43:12 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-73423</guid>
		<description>To complexify, if not temper, the enthusiasm, see 

DCA: Cancer Breakthrough or Urban Legend?
Enthusiasm Outpacing Science in Possible Cancer Therapy Discovery
OPINION by LEN LICHTENFELD, M.D.
Feb. 5, 2007 â€” 


&quot;There is the medical equivalent of a tsunami wave building out there, only we don&#039;t know where this one is going to land . . ..

In one group of rats where DCA was given after the injected tumors had been allowed to grow, the tumors immediately (in the authors&#039; words) decreased in size. 

So far, so good. 

But here is where things begin to get a bit dicey. 

These are quotes taken directly from the article. The first is from a summary printed at the bottom of the first page of the report: 

&quot;The ease of delivery, selectivity, and effectiveness make DCA an attractive candidate for proapoptotic cancer therapy which can be rapidly translated into phase II-III clinical trials.&quot; 

In the discussion section of the paper, the authors conclude with the following statement: 

&quot;Our work &amp; offers a tantalizing suggestion that DCA may have selective anticancer efficacy in patients. The very recent report of the first randomized long-term clinical trial of oral DCA in children with congenital lactic acidosis (at doses similar to those used in our in vivo experiments) showing that DCA was well tolerated and safe (Stacpoole et al., 2006) suggests a potentially easy translation of our work to clinical oncology.&quot; (Emphasis mine) 

In other words, the authors are saying that in their opinion these experiments in the lab and rats suggests that DCA may be a simple, effective treatment for cancer and we should move forward with clinical trials based solely on their theory and their results. 

I am not being critical of the authors&#039; comments, except for describing this as a &quot;potentially easy&quot; process. Nothing in translation from the bench to the bedside is easy. 

This is not the first time such suggestive statements have been made. In fact, these types of comments are not unusual in papers of this type. 

What I am critical of is the lack of discrimination in judgment of other folks -- not the researchers -- who have picked up on these lines and rapidly circulated the thought that we have a cure for cancer at hand, and that we must stop doing everything else and get this simple, safe and effective treatment to cancer patients immediately. 

 . . . .

The Facts About DCA
Please try to understand that I am not saying this is a theory that won&#039;t work. It may, and if it does prove valuable, that would be terrific. 

It is just that I have been around a while and have seen this type of hope and hype just a few times too many. 

I have seen cancer patients&#039; hopes lifted and dashed so often that I can&#039;t help but be cautious and conservative in my thinking. 

Let&#039;s take a look at what we can say. 

First, I did a literature search on PubMed looking for articles with the terms dichloroacetic acid and cancer. 

Although I didn&#039;t have access to all of the articles, one underlying theme stood out: DCA is an organic chemical that causes liver cancer in laboratory mice when put in their drinking water. 

It is not nontoxic. It is a byproduct of another chemical called trichloroethylene (TCE), which has been a source of concern as a cancer-causing agent for some time. 

Here is what the Agency for Toxic Substances and Disease Registry has to say about TCE: 

&quot;HIGHLIGHTS: Trichloroethylene is a colorless liquid which is used as a solvent for cleaning metal parts. Drinking or breathing high levels of trichloroethylene may cause nervous system effects, liver and lung damage, abnormal heartbeat, coma, and possibly death.&quot; 

So before you start going out and adding DCA to your drinking water to prevent cancer, a degree of caution would be very prudent at this point. 

. . . .

It is indeed a long, difficult road that must be traveled to demonstrate that an exciting new idea actually works in the treatment of cancer. 

So, pardon me if I am a skeptic. As Jessica Rabbit said, &quot;I am just drawn that way.&quot; 

But I am also an optimist, as I have said many times in these pages. I do believe that there are exciting new developments in cancer treatment emerging from laboratories around the world. Maybe DCA is one of them. 

It&#039;s just that I believe in patience, prudence and caution, because my experience has taught me that those are the best guidelines to follow in assessing reports such as the one in Cancer Cell. 

It is way too soon to know whether this is a cancer treatment breakthrough or an urban legend or something in between.&quot;</description>
		<content:encoded><![CDATA[<p>To complexify, if not temper, the enthusiasm, see </p>
<p>DCA: Cancer Breakthrough or Urban Legend?<br />
Enthusiasm Outpacing Science in Possible Cancer Therapy Discovery<br />
OPINION by LEN LICHTENFELD, M.D.<br />
Feb. 5, 2007 â€” </p>
<p>&#8220;There is the medical equivalent of a tsunami wave building out there, only we don&#8217;t know where this one is going to land . . ..</p>
<p>In one group of rats where DCA was given after the injected tumors had been allowed to grow, the tumors immediately (in the authors&#8217; words) decreased in size. </p>
<p>So far, so good. </p>
<p>But here is where things begin to get a bit dicey. </p>
<p>These are quotes taken directly from the article. The first is from a summary printed at the bottom of the first page of the report: </p>
<p>&#8220;The ease of delivery, selectivity, and effectiveness make DCA an attractive candidate for proapoptotic cancer therapy which can be rapidly translated into phase II-III clinical trials.&#8221; </p>
<p>In the discussion section of the paper, the authors conclude with the following statement: </p>
<p>&#8220;Our work &amp; offers a tantalizing suggestion that DCA may have selective anticancer efficacy in patients. The very recent report of the first randomized long-term clinical trial of oral DCA in children with congenital lactic acidosis (at doses similar to those used in our in vivo experiments) showing that DCA was well tolerated and safe (Stacpoole et al., 2006) suggests a potentially easy translation of our work to clinical oncology.&#8221; (Emphasis mine) </p>
<p>In other words, the authors are saying that in their opinion these experiments in the lab and rats suggests that DCA may be a simple, effective treatment for cancer and we should move forward with clinical trials based solely on their theory and their results. </p>
<p>I am not being critical of the authors&#8217; comments, except for describing this as a &#8220;potentially easy&#8221; process. Nothing in translation from the bench to the bedside is easy. </p>
<p>This is not the first time such suggestive statements have been made. In fact, these types of comments are not unusual in papers of this type. </p>
<p>What I am critical of is the lack of discrimination in judgment of other folks &#8212; not the researchers &#8212; who have picked up on these lines and rapidly circulated the thought that we have a cure for cancer at hand, and that we must stop doing everything else and get this simple, safe and effective treatment to cancer patients immediately. </p>
<p> . . . .</p>
<p>The Facts About DCA<br />
Please try to understand that I am not saying this is a theory that won&#8217;t work. It may, and if it does prove valuable, that would be terrific. </p>
<p>It is just that I have been around a while and have seen this type of hope and hype just a few times too many. </p>
<p>I have seen cancer patients&#8217; hopes lifted and dashed so often that I can&#8217;t help but be cautious and conservative in my thinking. </p>
<p>Let&#8217;s take a look at what we can say. </p>
<p>First, I did a literature search on PubMed looking for articles with the terms dichloroacetic acid and cancer. </p>
<p>Although I didn&#8217;t have access to all of the articles, one underlying theme stood out: DCA is an organic chemical that causes liver cancer in laboratory mice when put in their drinking water. </p>
<p>It is not nontoxic. It is a byproduct of another chemical called trichloroethylene (TCE), which has been a source of concern as a cancer-causing agent for some time. </p>
<p>Here is what the Agency for Toxic Substances and Disease Registry has to say about TCE: </p>
<p>&#8220;HIGHLIGHTS: Trichloroethylene is a colorless liquid which is used as a solvent for cleaning metal parts. Drinking or breathing high levels of trichloroethylene may cause nervous system effects, liver and lung damage, abnormal heartbeat, coma, and possibly death.&#8221; </p>
<p>So before you start going out and adding DCA to your drinking water to prevent cancer, a degree of caution would be very prudent at this point. </p>
<p>. . . .</p>
<p>It is indeed a long, difficult road that must be traveled to demonstrate that an exciting new idea actually works in the treatment of cancer. </p>
<p>So, pardon me if I am a skeptic. As Jessica Rabbit said, &#8220;I am just drawn that way.&#8221; </p>
<p>But I am also an optimist, as I have said many times in these pages. I do believe that there are exciting new developments in cancer treatment emerging from laboratories around the world. Maybe DCA is one of them. </p>
<p>It&#8217;s just that I believe in patience, prudence and caution, because my experience has taught me that those are the best guidelines to follow in assessing reports such as the one in Cancer Cell. </p>
<p>It is way too soon to know whether this is a cancer treatment breakthrough or an urban legend or something in between.&#8221;</p>
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		<title>By: hurley</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-73374</link>
		<dc:creator>hurley</dc:creator>
		<pubDate>Sat, 23 Jun 2007 09:31:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-73374</guid>
		<description>An angle almost as bleak:
http://www.nytimes.com/2006/08/13/us/13inmates.html?ex=1182744000&amp;en=2927082924c50bcc&amp;ei=5070
Google &quot;drug trials in prisons&quot; and you&#039;ll find more than you want to know.</description>
		<content:encoded><![CDATA[<p>An angle almost as bleak:<br />
<a href="http://www.nytimes.com/2006/08/13/us/13inmates.html?ex=1182744000&amp;en=2927082924c50bcc&amp;ei=5070" rel="nofollow">http://www.nytimes.com/2006/08/13/us/13inmates.html?ex=1182744000&amp;en=2927082924c50bcc&amp;ei=5070</a><br />
Google &#8220;drug trials in prisons&#8221; and you&#8217;ll find more than you want to know.</p>
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		<title>By: enhabit</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-73310</link>
		<dc:creator>enhabit</dc:creator>
		<pubDate>Fri, 22 Jun 2007 16:14:00 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-73310</guid>
		<description>bbc on unauthorized drug trials in Nigeria..not a new story but shocking anyway.

http://news.bbc.co.uk/2/hi/africa/6768799.stm

we like to think that weâ€™ve come farther than thisâ€¦shameful doesnâ€™t even begin to describe itâ€¦pfizer!</description>
		<content:encoded><![CDATA[<p>bbc on unauthorized drug trials in Nigeria..not a new story but shocking anyway.</p>
<p><a href="http://news.bbc.co.uk/2/hi/africa/6768799.stm" rel="nofollow">http://news.bbc.co.uk/2/hi/africa/6768799.stm</a></p>
<p>we like to think that weâ€™ve come farther than thisâ€¦shameful doesnâ€™t even begin to describe itâ€¦pfizer!</p>
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		<title>By: BJ</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-73196</link>
		<dc:creator>BJ</dc:creator>
		<pubDate>Thu, 21 Jun 2007 20:26:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-73196</guid>
		<description>In answer to David&#039;s last question citizen-funded research is very much with us now, especially as the NIH support for medical research stagnates. The difference is that the &quot;ask&quot; is usually made by the institution&#039;s development department rather than the researcher. Go to any cancer-research center&#039;s site and you&#039;ll find a &quot;give&quot; button prominently displayed. It will usually lead you to a page explaining that your contribution will support &quot;our compassionate patient care and groundbreaking research.&quot; The groundbreaking research can, in some instances, include clinical trials. 

In the &lt;em&gt;Nature Clinical Practice&lt;/em&gt; item that duplicity links to, the writer notes that the &lt;em&gt;structure&lt;/em&gt; of DCA can&#039;t be patented, which is true. However, Michelakis does hold a &lt;em&gt;use&lt;/em&gt; patent on the molecule, which essentially gives him exclusive rights to develop it for use as an anti-cancer agent. (There&#039;s a link to his patent on thedcasite.org).  If the drug showed any indication of becoming a blockbuster in treating human cancer, it seems likely that the major pharmaceutical manufacturers would be in a bidding war to license it from Michelakis. Moreover, academic technology transfer programs, which are becoming increasingly important sources of institutional revenue, are loathe to let go of a promising new agent; When you do the show, you might want to talk to someone from TecEdmonton, the University of Alberta&#039;s tech transfer office, to see why they withdrew their sponsorship from DCA.

While DCA may be a great new tool in the oncologic armentarium it seems equally likely that it could be this era&#039;s laetrile.</description>
		<content:encoded><![CDATA[<p>In answer to David&#8217;s last question citizen-funded research is very much with us now, especially as the NIH support for medical research stagnates. The difference is that the &#8220;ask&#8221; is usually made by the institution&#8217;s development department rather than the researcher. Go to any cancer-research center&#8217;s site and you&#8217;ll find a &#8220;give&#8221; button prominently displayed. It will usually lead you to a page explaining that your contribution will support &#8220;our compassionate patient care and groundbreaking research.&#8221; The groundbreaking research can, in some instances, include clinical trials. </p>
<p>In the <em>Nature Clinical Practice</em> item that duplicity links to, the writer notes that the <em>structure</em> of DCA can&#8217;t be patented, which is true. However, Michelakis does hold a <em>use</em> patent on the molecule, which essentially gives him exclusive rights to develop it for use as an anti-cancer agent. (There&#8217;s a link to his patent on thedcasite.org).  If the drug showed any indication of becoming a blockbuster in treating human cancer, it seems likely that the major pharmaceutical manufacturers would be in a bidding war to license it from Michelakis. Moreover, academic technology transfer programs, which are becoming increasingly important sources of institutional revenue, are loathe to let go of a promising new agent; When you do the show, you might want to talk to someone from TecEdmonton, the University of Alberta&#8217;s tech transfer office, to see why they withdrew their sponsorship from DCA.</p>
<p>While DCA may be a great new tool in the oncologic armentarium it seems equally likely that it could be this era&#8217;s laetrile.</p>
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		<title>By: hurley</title>
		<link>http://www.radioopensource.org/the-diy-clinical-trial/comment-page-1/#comment-72573</link>
		<dc:creator>hurley</dc:creator>
		<pubDate>Thu, 21 Jun 2007 11:05:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.radioopensource.org/?p=1132#comment-72573</guid>
		<description>Great suggestion, duplicity. This is an inspiring example of human ingenuity and defiance against the odds, and an absolutely desolating commentary on corporate medicine and the state of health care in the US. I&#039;ve spent an awful lot of time -- the cliche for once suits -- in cancer wards (with family) and a lot of equally desperate time trying to plot a strategy in the sort of three-dimensional chess universe a cancer victim enters upon diagnosis, particularly a cancer victim of modest means. Is the diagnosis correct? What are the options? Is the oncologist offering me the protocol best suited to my particular cancer, or the one he happens to trade in? The pharma he happens to trade in? Why is he so reluctant to answer my questions? Why does he underprescribe the morphine?  What actuarial calculation is in play with the insurance company, and why does it refuse to pay for further treatment? And what of the &quot;alternative&quot; therapies? Does shit and shinola really send tumors into remission? Is that a chicken liver you just pulled out of my side? You want me to pay you what?!
Why not invite Elizabeth Edwards to discuss the subject? And farther down the road you might consider John Le CarrÃ©. He wrote a pretty angry novel on Big Pharma.</description>
		<content:encoded><![CDATA[<p>Great suggestion, duplicity. This is an inspiring example of human ingenuity and defiance against the odds, and an absolutely desolating commentary on corporate medicine and the state of health care in the US. I&#8217;ve spent an awful lot of time &#8212; the cliche for once suits &#8212; in cancer wards (with family) and a lot of equally desperate time trying to plot a strategy in the sort of three-dimensional chess universe a cancer victim enters upon diagnosis, particularly a cancer victim of modest means. Is the diagnosis correct? What are the options? Is the oncologist offering me the protocol best suited to my particular cancer, or the one he happens to trade in? The pharma he happens to trade in? Why is he so reluctant to answer my questions? Why does he underprescribe the morphine?  What actuarial calculation is in play with the insurance company, and why does it refuse to pay for further treatment? And what of the &#8220;alternative&#8221; therapies? Does shit and shinola really send tumors into remission? Is that a chicken liver you just pulled out of my side? You want me to pay you what?!<br />
Why not invite Elizabeth Edwards to discuss the subject? And farther down the road you might consider John Le CarrÃ©. He wrote a pretty angry novel on Big Pharma.</p>
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